IGF-1 LR3 (Long R3 IGF-1) raw materials

IGF-1 LR3 Raw Material (Insulin-like Growth Factor-1 LR3)

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a long-acting, active analog of natural IGF-1. By replacing the glutamic acid at position 3 with arginine and extending the N-terminal sequence, its affinity for binding proteins is significantly reduced, and its half-life is much longer than that of natural IGF-1 (12-15 hours vs. less than 1 hour), making it a core molecular tool in growth factor research.

Key Biological Activities

• Promotes Cell Proliferation and Differentiation: Potently promotes the proliferation of various cell types by activating the IGF-1R signaling pathway (PI3K/Akt, MAPK/ERK), widely used in in vitro cell culture research.
• Anabolic Activation: Promotes protein synthesis and inhibits AMPK-mediated catabolism, supporting research related to muscle anabolism.
• Anti-Apoptosis and Cell Survival: Inhibits apoptosis via the Akt/Bad pathway, prolongs cell survival time, and is applied in research for the protection of neural cells, muscle cells, and myocardial cells.
• Bone, Cartilage, and Connective Tissue Research: Promotes osteoblast differentiation and inhibits osteoclast activity, applied in research fields related to osteoporosis and bone regeneration.
• Neural Repair and Protection: In neuroscience research, it demonstrates nutritional support for neuronal cells and promotes neurite growth.
• Long-acting Advantage: Extremely low affinity for binding proteins, allowing for long-term signal activation in culture media, significantly superior to natural IGF-1 in terms of experimental application efficiency.

Product Features

• Research-grade purity, suitable for in vitro experiments, cell culture, animal models, and drug discovery research.
• High chemical stability and excellent consistency in biological activity between batches.

This product is a research-grade raw material and is for scientific research use only.