MOTS-c (Mitochondrial-Derived Peptide C) raw materials

MOTS-c Raw Material (Mitochondrial-derived Micropeptide C)

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is an endogenous micropeptide encoded by the mitochondrial genome, consisting of only 16 amino acids. It transduces mitochondrial signals to the cell nucleus, regulating nuclear-encoded gene expression. It is an important frontier raw material for research in mitochondrial signaling and metabolic regulation.

Main Bioactivities

• Activates AMPK Signaling Pathway: Enters the cell nucleus to activate AMPK (AMP-activated protein kinase), promoting fatty acid oxidation and glucose uptake, and inhibiting anabolism. It is a valuable tool molecule for research related to mitochondrial metabolic activation.
• Improved Insulin Sensitivity: Animal studies show that MOTS-c can significantly improve insulin sensitivity, reduce blood glucose, and lower body weight in high-fat, high-sugar mouse models, making it suitable for research into the mechanisms of metabolic syndrome.
• Enhanced Exercise Endurance: Promotes mitochondrial biogenesis and aerobic metabolic capacity in skeletal muscle models, demonstrating exercise-mimicking effects, making it suitable for muscle metabolism and exercise science research.
• Anti-aging and Longevity Research: Plasma MOTS-c concentrations increase with age. Supplementation with exogenous MOTS-c has shown potential in improving physiological indicators in longevity-related research, making it a popular research target in the anti-aging field.
• Anti-inflammatory and Immunomodulatory: Can regulate the expression of various inflammatory factors and has shown protective effects in chronic inflammation models, making it suitable for research at the intersection of immunology and metabolism.
• Bone Protection: Studies show a protective effect on models related to osteoporosis, making it an emerging tool molecule in the field of bone biology research.

Product Features

• Research-grade purity, high consistency of bioactivity between batches.
• Suitable for in vitro experiments, animal models, and applied research.

This product is a research-grade raw material and is for scientific research use only.